7th IMRMPT

Abstract

Abstract information

English title:	Bactericidal surface treatments for dental implants based on silver and copper ion co-implantation
Spanish title:	Tratamientos superficiales bactericidas para implantes dentales basados en la co-implantaci�n i�nica de plata y cobre
English abstract:	In the field of dental implantology, the widespread use of dental implants has been one of the most important changes and advances in dental practice in recent years. However, in spite of the predictability of dental implant treatments, which show success rates of around 90% after 10 years of insertion, there are still important problems to overcome, with a group of pathologies that cause the loss of peri-implant bone and, finally, the loss of the implant. In particular, infection caused by bacterial colonization (peri-implantitis) is one of the main causes of implant failure. Among the different approaches proposed to solve this problem, the surface treatment of implants by incorporating bactericidal metal ions (Cu, Ag, Zn) has been studied. Silver is by far the most effective biocidal metal element, acting on a broad spectrum of bacteria (both gram-negative and gram-positive), showing a low tendency to develop bacterial resistance, and inhibiting polymicrobial colonization. Its bactericidal efficacy has been demonstrated against pathogens commonly found in peri-implantitis: S. mutans, S. aureus, S. oralis, P. gingivalis and A. actinomycetemcomitans. Moreover, since ancient times, copper ion has been recognized as a potent bactericidal agent agaisnt a wide range of bacteria, fungi and viruses. On the basis of the foregoing, in this work, bactericidal surface treatments on titanium grade 4 have been developed by means of silver and copper ion co-implantation using a Metal Vapor Vacuum Arc (MEVVA) ion source. Morphology, structure and silver/copper concentration depth profile were characterized by SEM and XPS as a function of ion implantation voltage and dose. Mechanical properties were analyzed by means of nanoindentation. Cytotoxicity was studied using mammal fibroblasts BALB/3T3. The antibacterial activity against S. aureus and E. coli, and the resistance to the formation of a biofilm composed of the bacteria F. nucleatum, P. gingivalis and A. actimomycetemcomitans was analyzed.
Spanish abstract:	En el campo de la implantolog�a dental, el uso generalizado de implantes dentales ha supuesto uno de los cambios y avances m�s importantes en la pr�ctica odontol�gica de los �ltimos a�os. Sin embargo, a pesar de la predictibilidad de los tratamientos con implantes dentales, que presentan tasas de �xito en torno al 90% a los 10 a�os de su colocaci�n, todav�a existen importantes problemas que superar, con un conjunto de patolog�as que provocan la p�rdida de hueso periimplantario y, finalmente, la p�rdida del implante. En particular, la infecci�n causada por la colonizaci�n bacteriana (periimplantitis) es una de las principales causas de fracaso de los implantes. Entre los distintos enfoques propuestos para resolver este problema, se ha estudiado el tratamiento superficial de los implantes mediante la incorporaci�n de iones met�licos bactericidas (Cu, Ag, Zn). La plata es, con diferencia, el elemento met�lico biocida m�s eficaz, ya que act�a sobre un amplio espectro de bacterias (tanto gramnegativas como grampositivas), muestra una baja tendencia a desarrollar resistencia bacteriana e inhibe la colonizaci�n polimicrobiana. Se ha demostrado su eficacia bactericida frente a pat�genos com�nmente encontrados en la periimplantitis: S. mutans, S. aureus, S. oralis, P. gingivalis y A. actinomycetemcomitans. Adem�s, desde la antig�edad, el cobre ha sido reconocido como un potente agente bactericida contra una amplia gama de bacterias, hongos y virus. En base a lo anterior, en este trabajo se han desarrollado tratamientos superficiales bactericidas sobre titanio grado 4 mediante co-implantaci�n de iones de plata y cobre utilizando una fuente de iones Metal Vapor Vacuum Arc (MEVVA). La morfolog�a, estructura y perfil de profundidad de concentraci�n de plata/cobre se caracterizaron mediante SEM y XPS en funci�n del voltaje y dosis de implantaci�n i�nica. Las propiedades mec�nicas se analizaron mediante nanoindentaci�n. La citotoxicidad se estudi� utilizando fibroblastos de mam�fero BALB/3T3. Se analiz� la actividad antibacteriana frente a S. aureus y E. coli, y la resistencia a la formaci�n de un biofilm compuesto por las bacterias F. nucleatum, P. gingivalis y A. actimomycetemcomitans.
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Authors

Name	Institution	Email
JAIME CARO PRADOS	FUNDACI� EURECAT	jaume.caro@eurecat.org
Ra�l Bonet Montserrat	FUNDACI� EURECAT	raul.bonet@eurecat.org
Jordi Orrit-Prat	FUNDACIO EURECAT	jordi.orrit@eurecat.org
Joan Mu�oz Villanueva	MICRODENT IMPLANT SYSTEM S.L.	joan@microdentsystem.com

Presentation

Room:	Principal Room
Date:	June 8, 2023
Hour:	10:30 - 11:00

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7^th IMRMPT
Seventh International Meeting for Researchers in Materials and Plasma Technology

Previous editions:

        1st IMRMPT 2011
        2nd IMRMPT 2013
        3rd IMRMPT 2015
        4th IMRMPT 2017
        5th IMRMPT 2019
        5+1 IMRMPT 2021

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